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Chemical Structure : STING inhibitor H-151
CAS No.: 941987-60-6
Catalog No.: PC-35312Not For Human Use, Lab Use Only.
STING inhibitor H-151 (H151) is a highly potent, selective, covalent small-molecule antagonist of STING that has noteworthy inhibitory activity both in human cells and in vivo.
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|---|---|---|---|
| 5 mg (Free Sample) | $8 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
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STING inhibitor H-151 (H151) is a highly potent, selective, covalent small-molecule antagonist of STING that has noteworthy inhibitory activity both in human cells and in vivo。
The irreversible modification introduced by H-151 to hsSTING again is dependent on Cys91.
H-151 markedly reduces systemic cytokine responses in CMA-treated mice.
| M.Wt | 279.343 | |
| Formula | C17H17N3O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea |
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1. Haag SM, et al. Nature. 2018 Jul 4. doi: 10.1038/s41586-018-0287-8.
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