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Chemical Structure : SUN11602
CAS No.: 704869-38-5
Catalog No.: PC-42401Not For Human Use, Lab Use Only.
A novel aniline compound that mimics the neuroprotective effects of bFGF by activating FGFR1-MEK/ERK signaling pathway.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $120 | In stock | |
| 25 mg | $232 | In stock | |
| 50 mg | $360 | In stock | |
| 100 mg | $640 | In stock |
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A novel aniline compound that mimics the neuroprotective effects of bFGF by activating FGFR1-MEK/ERK signaling pathway; prevents glutamate-induced neuronal death in primary cultures of rat cerebrocortical neurons, augments phosphorylation of FGFR-1 and ERK-1/2, increases the levels of CALB1 gene expression; increases the levels of newly synthesized calcium-binding protein calbindin-D28k (Calb) in cerebrocortical neurons and suppresses the glutamate-induced rise in intracellular Ca(2+) in WT mice; attenuates neuronal damage and cognitive deficits in a rat model of Alzheimer's disease.
| M.Wt | 451.60428 | |
| Formula | C26H37N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 37 mg/mL |
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| Chemical Name/SMILES |
Benzamide, 4-[[4-[[2-[(4-amino-2,3,5,6-tetramethylphenyl)amino]acetyl]methylamino]-1-piperidinyl]methyl]- |
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1. Murayama N, et al. ACS Chem Neurosci. 2013 Feb 20;4(2):266-76.
2. Ogino R, et al. Brain Res. 2014 Oct 17;1585:159-66.
3. Murayama N, et al. Brain Res. 2015 Jan 12;1594:71-81.
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