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Chemical Structure : SUVN-911
CAS No.: 2414674-71-6
Catalog No.: PC-72169Not For Human Use, Lab Use Only.
SUVN-911 (Ropanicant) is a novel, potent, selective, orally active α4β2 nAChR receptor antagonist with Ki of 1.5 nM.
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|---|---|---|---|
| 5 mg | $268 | In stock | |
| 25 mg | $658 | In stock | |
| 100 mg | Get quote |
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SUVN-911 (Ropanicant) is a novel, potent, selective, orally active α4β2 nAChR receptor antagonist with Ki of 1.5 nM.
SUVN-911 dispalys negligible binding affinity toward the ganglionic α3β4 receptor apart from showing selectivity over 70 other targets.
SUVN-911 is orally bioavailable and showed good brain penetration in rats.
SUVN-911 demonstrated significant antidepressant activity and dose-dependent receptor occupancy in rats, does not affect the locomotor activity at doses several folds higher than its efficacy dose and is devoid of cardiovascular and gastrointestinal side effects,
SUVN-911 shows potential therapeutic utility in the treatment of depression.
| M.Wt | 261.146 | |
| Formula | C11H14Cl2N2O | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Ramakrishna Nirogi, et al. J Med Chem. 2020 Mar 26;63(6):2833-2853.
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