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SW-033291

Chemical Structure : SW-033291

CAS No.: 459147-39-8

SW-033291 (SW033291)

Catalog No.: PC-45107Not For Human Use, Lab Use Only.

A potent and selective inhibitor of 15-PGDH with Ki of 0.1 nM, IC50 of 1.5 nM.

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10 mg $120 In stock
50 mg $360 In stock
100 mg $520 In stock

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A potent and selective inhibitor of 15-PGDH with Ki of 0.1 nM, IC50 of 1.5 nM; increases PGE2 levels by 3.5-fold at 500 nM, with EC50 of 75 nM; increases prostaglandin PGE2 levels in bone marrow and other tissues, accelerates hematopoietic recovery in mice receiving a bone marrow transplant; also promotes tissue regeneration in mouse models of colon and liver injury.

Physicochemical Properties

M.Wt 412.5913
Formula C21H20N2OS3
CAS No. 459147-39-8
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name

Thieno[2,3-b]pyridin-3-amine, 2-(butylsulfinyl)-4-phenyl-6-(2-thienyl)-

References

1. Zhang Y, et al. Science. 2015 Jun 12;348(6240):aaa2340.

2. Antczak MI, et al. J Med Chem. 2017 May 11;60(9):3979-4001.

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