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SW155246

Chemical Structure : SW155246

CAS No.: 420092-79-1

SW155246 (SW 155246)

Catalog No.: PC-38486Not For Human Use, Lab Use Only.

SW155246 is a potent, selective antagonis/inhibitor of DNA methyltransferase DNMT1 with IC50 of 1.2 uM against hDNMT1, 30-fold preference versus human or murine DNMT3A or -3B (IC50=38 uM).

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Biological Activity

SW155246 is a potent, selective antagonis/inhibitor of DNA methyltransferase DNMT1 with IC50 of 1.2 uM against hDNMT1, 30-fold preference versus human or murine DNMT3A or -3B (IC50=38 uM).
SW155246 showed a variable degree of cell-growth inhibition against HeLa and A549 with IC50 of 8-20 uM.
SW155246 inhibited global methylation in HeLa cells, reactivated expression of the tumor suppressor gene RASSF1A in A549 cells.

Physicochemical Properties

M.Wt 378.8
Formula C16H11ClN2O5S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4-chloro-N-(4-hydroxy-1-naphthalenyl)-3-nitro-benzenesulfonamide

References

1. Kilgore JA, et al. J Biol Chem. 2013 Jul 5;288(27):19673-84.

2. Medina-Franco JL, et al. Int J Mol Sci. 2014 Feb 21;15(2):3253-61.

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