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Chemical Structure : SYC-435
Catalog No.: PC-35207Not For Human Use, Lab Use Only.
SYC-435 (SYC435) is a potent inhibitor of mutant IDH1, binds at the isocitrate pocket of mutated IDH1 with Ki values of 190 nM against IDH1 R132H and 120 nM against IDH1 R132C.
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SYC-435 (TC-E 5008) is a potent inhibitor of mutant IDH1, binds at the isocitrate pocket of mutated IDH1 with Ki values of 190 nM against IDH1 R132H and 120 nM against IDH1 R132C.
SYC-435 is cell active and capable of significantly reducing D-2-HG production in an HT1080 fibrosarcoma cell line expressing IDH1 R132C (IC50=2.4 uM).
| M.Wt | 215.252 | |
| Formula | C13H13NO2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Liu Z, et al. J Med Chem. 2014 Oct 23;57(20):8307-18.
2. Ma T, et al. J Med Chem. 2018 Jun 18. doi: 10.1021/acs.jmedchem.8b00159.
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