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Chemical Structure : SYL1073
Catalog No.: PC-21597Not For Human Use, Lab Use Only.
SYL1073 is a potent, selective and covalent Threonine tyrosine kinase (TTK) inhibitor with IC50 of of 16 nM.
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SYL1073 is a potent, selective and covalent Threonine tyrosine kinase (TTK) inhibitor with IC50 of of 16 nM.
SYL1073 covalently engages with TTK at the C604 residue.
SYL1073 exhibits potent anti-proliferative activity in both MDA-MB-231 (IC50 = 0.13 μM) and HCT-116 (IC50 = 0.15 μM) cell lines.
SYL1073 exhibits excellent kinase selectivity in a panel of kinases, does not inhibit five other human kinases (CHAK1, FGFR4, MAPKAPK2, MAPKAPK3 and p70S6Kβ) that feature a cysteine residue at the equivalent position as C604 in TTK kinase.
SYL1073 effectively suppresses colony formation and induce cell cycle dysregulation and apoptosis in human breast cancer cells.
| M.Wt | 471.57 | |
| Formula | C25H29N9O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Yaoliang Sun, et al. Bioorg Chem. 2023 Dec 25:143:107053.
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