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Chemical Structure : SYN1143
CAS No.: 913376-84-8
Catalog No.: PC-49518Not For Human Use, Lab Use Only.
SYN1143 (AMG-1) is a potent specific small molecule inhibitor of c-Met kinase and RON with IC50 of 4 and 9 nM, inhibits c-Met signaling and cell proliferation in vitro.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg (Free Sample) | $18 | In stock | |
| 5 mg | $128 | In stock | |
| 10 mg | $198 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SYN1143 (AMG-1) is a potent specific small molecule inhibitor of c-Met kinase and RON with IC50 of 4 and 9 nM, inhibits c-Met signaling and cell proliferation in vitro.
SYN1143 significantly increases ALP activity at concentration 1 uM in MC3T3-E1 cells.
SYN1143 increases Runx2 via pathway independent of Erk-Smad.
SYN1143 (20, 50 μg) stimulates bone formation in critical-sized defects of mouse calvarial bone in a critical-sized calvarial defect of mouse.
| M.Wt | 556.594 | |
| Formula | C31H29FN4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(3-fluoro-4-((7-methoxy-4-quinolinyl)oxy)phenyl)-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide |
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1. Zhang Y, et al. Cancer Res. 2008 Aug 15;68(16):6680-7.
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