SZL P1-41 (SZL-P1-41) is a small molecule Skp2 E3 ligase inhibitor that prevents Skp2-Skp1 interaction and Skp2 SCF E3 ligase activity in vitro.
SZL P1-41 specifically diminishes E3-ligase activity of Skp2-SCF complex, but not of other F-box SCF complex.
SZL P1-41 inhibits Skp2-mediated p27 ubiquitination, induced endogenous p27 protein expression in prostate cancer cells.
SZL P1-41 exhibits potent antitumor activities in multiple animal models and cooperates with chemotherapeutic agents to reduce cancer cell survival.
