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Chemical Structure : SZL P1-41
CAS No.: 222716-34-9
Catalog No.: PC-42099Not For Human Use, Lab Use Only.
SZL P1-41 (SZL-P1-41) is a small molecule Skp2 E3 ligase inhibitor that prevents Skp2-Skp1 interaction and Skp2 SCF E3 ligase activity in vitro.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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SZL P1-41 (SZL-P1-41) is a small molecule Skp2 E3 ligase inhibitor that prevents Skp2-Skp1 interaction and Skp2 SCF E3 ligase activity in vitro.
SZL P1-41 specifically diminishes E3-ligase activity of Skp2-SCF complex, but not of other F-box SCF complex.
SZL P1-41 inhibits Skp2-mediated p27 ubiquitination, induced endogenous p27 protein expression in prostate cancer cells.
SZL P1-41 exhibits potent antitumor activities in multiple animal models and cooperates with chemotherapeutic agents to reduce cancer cell survival.
| M.Wt | 420.524 | |
| Formula | C24H24N2O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
4H-1-Benzopyran-4-one, 3-(2-benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)- |
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1. Chan CH, et al. Cell. 2013 Aug 1;154(3):556-68.
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