Chemical Structure : SZM-1209
CAS No.:
2919801-86-6
SZM-1209
(SZM1209)
Catalog No.: PC-24512Not For Human Use, Lab Use Only.
SZM-1209 is a potent, specific RIPK1 inhibitor with Kd value of 85 nM, >100-fold selective over RIPK3, exhibits anti-necroptosis activity against human HT-29 cells with EC50 of 22.4 nM.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
SZM-1209 is a potent, specific RIPK1 inhibitor with Kd value of 85 nM, >100-fold selective over RIPK3, exhibits anti-necroptosis activity against human HT-29 cells with EC50 of 22.4 nM.
SZM-1209 specifically inhibits necroptosis signaling rather apoptosis, dose-relatedly inhibits necroptosis and almost 100% protectionat 50 nM.
SZM-1209 specifically inhibits phosphorylation of RIPK1-RIPK3-MLKL necroptosis signaling.
SZM-1209 (10 and 20 mg/kg) effectively protect against mTNFα-induced systemic inflammatory response syndrome (SIRS) model in vivo.
SZM-1209 significantly alleviated ALI by reducing pulmonary edema and pathological damage in NNK short-term intratracheal exposure-induced ALI model.
Physicochemical Properties
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M.Wt
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696.71
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Formula
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C31H29F5N4O5S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-(ethylsulfonamido)-N-(5-fluoro-6-(4-fluoro-3-(2-(3-(trifluoromethyl)phenyl)acetamido)phenoxy)benzo[d]thiazol-2-yl)cyclohexane-1-carboxamide
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References
1. Zhang X, et al. J Med Chem. 2023 Apr 13;66(7):5261-5278.
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