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Saikosaponin A

Chemical Structure : Saikosaponin A

CAS No.: 20736-09-8

Saikosaponin A

Catalog No.: PC-27753Not For Human Use, Lab Use Only.

Saikosaponin A is a triterpenoid saponin derived from Bupleurum root, exhibits neuroprotective and anti-inflammatory properties, modulates neuroprotective pathways associated with transcription factor NURR1 expression.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Saikosaponin A is a triterpenoid saponin derived from Bupleurum root, exhibits neuroprotective and anti-inflammatory properties, modulates neuroprotective pathways associated with transcription factor NURR1 expression, also is a potential PPARγ agonist, significantly promoting the expression of PPAR-γ

Physicochemical Properties

M.Wt 780.99
Formula C42H68O13
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2S,3R,4S,5S,6R)-2-(((2R,3R,4S,5S,6R)-3,5-Dihydroxy-2-(((3S,4R,4aR,6aR,6bS,8S,8aS,12aR,12bS,14aR,14bS)-8-hydroxy-4-(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-2,3,4,4a,5,6,6a,6b,7,8,10,11,12,12a,14a,14b-hexadecahydro-1H,9H-12b,8a-(epoxymethano)picen-3-yl)oxy)-6-methyltetrahydro-2H-pyran-4-yl)oxy)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol

References

1. Li Y, et al. Phytomedicine. 2026 Aug;158:158414.

2. Yang J, et al. J Inflamm Res. 2026 May 22;19:592311.

3. Zhang Y, et al. Behav Brain Res. 2026 Feb 28;499:115968.

4. Huh E, et al. Pharmacol Rep. 2026 Feb;78(1):264-276.

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