Chemical Structure : Salvage-1
CAS No.:
2791116-48-6
Salvage-1
(Salvage 1, Salvage1)
Catalog No.: PC-26888Not For Human Use, Lab Use Only.
Salvage-1 is a selective, positive allosteric modulator (PAM) of α4β2 nAChRs, demonstrates potent antiarrhythmic efficacy.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Salvage-1 is a selective, positive allosteric modulator (PAM) of α4β2 nAChRs, demonstrates potent antiarrhythmic efficacy.
Salvage-1 suppresses re-entry through α4β2 nAChR-mediated enhancement of myocardial excitability and conductivity.
Salvage-1 selectively stabilizes the α4 subunit (CHRNA4), with minimal effect on the β2 subunit (CHRNB2), also shows weak inhibition of key cardiac ion channels, Cav1.2 and Nav1.5.
Salvage-1 selectively potentiates α4β2 nAChRs by interacting with residues Phe312 and Phe316 of α4 subunit, thereby stabilizing the receptor in its open-channel state.
Salvage-1 demonstrates marked antiarrhythmic efficacy in rodent models of fatal ventricular tachyarrhythmias (FVTs).
Salvage-1 demonstrates superior efficacy compared to lidocaine in both porcine and human models of FVTs.
Physicochemical Properties
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M.Wt
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325.37
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Formula
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C18H19N3O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-(5-methoxy-1H-indol-3-yl)-N-(2-nitrobenzyl)ethan-1-amine
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References
1. Xie D, et al. Eur Heart J. 2026 May 18:ehag293.
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