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Sapacitabine

Chemical Structure : Sapacitabine

CAS No.: 151823-14-2

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Sapacitabine (CYC-682;CYC682)

Catalog No.: PC-61331Not For Human Use, Lab Use Only.

An orally available, nucleoside analog prodrug of CNDAC that interferes with DNA synthesis by causing single-strand DNA breaks.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

An orally available, nucleoside analog prodrug of CNDAC that interferes with DNA synthesis by causing single-strand DNA breaks; induces arrest of the cell division cycle at G2 phase, demonstrates potent anti-tumor activity in both blood and solid tumors.

Chemotherapeutic Agents

Phase 3 Clinical

Physicochemical Properties

M.Wt 490.64
Formula C26H42N4O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-[1-(2-Cyano-2-deoxy-β-D-arabinofuranosyl)-1,2-dihydro-2-oxo-4-pyrimidinyl]hexadecanamide

References

1. Hanaoka K, et al. Int J Cancer. 1999 Jul 19;82(2):226-36.

2. Wu M, et al. Cancer Res. 2003 May 15;63(10):2477-82.

3. Katz MH, et al. Cancer Res. 2003 Sep 1;63(17):5521-5.

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