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Chemical Structure : Sappanone A
Catalog No.: PC-70216Not For Human Use, Lab Use Only.
A homoisoflavanone found in Caesalpinia sappan, a potent, selective IMPDH2 inhibitor that covalently binds to Cys140 with Kd of 3.944 nM, almost 10 times lower than the Kd of binding to IMPDH1.
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A homoisoflavanone found in Caesalpinia sappan, a potent, selective IMPDH2 inhibitor that covalently binds to Cys140 with Kd of 3.944 nM, almost 10 times lower than the Kd of binding to IMPDH1; significantly suppresses the releases of NO (IC50=4.12 uM), TNF-α, IL-6, and PGE2 and decreases the gene expressions of TNF-α, IL-6, IL-1β, MCP-1, iNOS, and COX-2 in BV-2 cells; inhibits neuroinflammatory responses with high drug safety and less side effects in vivo.
| M.Wt | 284.26 | |
| Formula | C16H12O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Liao LX, et al. Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5986-E5994.
2. Kang L, et al. Int Immunopharmacol. 2016 Sep;38:246-51.
3. Lee S, et al. Int Immunopharmacol. 2015 Sep;28(1):328-36.
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