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Sauchinone

Chemical Structure : Sauchinone

CAS No.: 177931-17-8

Sauchinone

Catalog No.: PC-24477Not For Human Use, Lab Use Only.

Sauchinone is a diastereomeric lignan isolated from Saururus chinensis with anti-inflammatory and antioxidant activity, inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation, also is a novel TGR5 agonist.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Sauchinone is a diastereomeric lignan isolated from Saururus chinensis with anti-inflammatory and antioxidant activity, inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation, also is a novel TGR5 agonist.

Physicochemical Properties

M.Wt 356.37
Formula C20H20O6
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(5aR,5a1R,7R,8S,8aR,14aS)-7,8-Dimethyl-5a,5a1,6,7,8,8a-hexahydro-5H-benzo[kl]bis([1,3]dioxolo)[4,5-b:4',5'-g]xanthen-5-one

References

1. Lee AK, et al. Br J Pharmacol. 2003 May;139(1):11-20.

2. Wang HY, et al. J Adv Res. 2025 Apr 22:S2090-1232(25)00278-4.

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