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Chemical Structure : Semagacestat
CAS No.: 425386-60-3
Catalog No.: PC-42053Not For Human Use, Lab Use Only.
Semagacestat (LY-450139) is a potent γ-secretase inhibitor that inhibits β-amyloid Aβ42, Aβ38 and Aβ40 with IC50 of 10.9, 12 and 12.1 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg (Free Sample) | $18 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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Semagacestat (LY-450139) is a potent γ-secretase inhibitor that inhibits β-amyloid Aβ42, Aβ38 and Aβ40 with IC50 of 10.9, 12 and 12.1 nM, respectively.
Semagacestat (LY-450139) reduces the secretion of Aβ42, Aβ40, and Aβ38 in cells and increases β-CTF in cell lysates, also inhibits Notch signaling with IC50 of 14.1 nM.
Semagacestat (LY-450139) increases intracellular byproduct peptides, produced along with Aβ through serial γ-cleavage of βAPP, as well as intracellular long Aβ species, in cell-based and in vivo studies of AD model mice; a pseudo-inhibitor of γ-secretase.
| M.Wt | 361.4354 | |
| Formula | C19H27N3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Butanamide, 2-hydroxy-3-methyl-N-[(1S)-1-methyl-2-oxo-2-[[(1S)-2,3,4,5-tetrahydro-3-methyl-2-oxo-1H-3-benzazepin-1-yl]amino]ethyl]-, (2S)- |
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1. Lanz TA, et al. J Pharmacol Exp Ther. 2006 Nov;319(2):924-33.
2. Mitani Y, et al. J Neurosci. 2012 Feb 8;32(6):2037-50.
3. Elvang AB, et al. J Neurochem. 2009 Sep;110(5):1377-87.
4. Tagami S, et al. Cell Rep. 2017 Oct 3;21(1):259-273.
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