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Chemical Structure : Setmelanotide
CAS No.: 920014-72-8
Catalog No.: PC-45743Not For Human Use, Lab Use Only.
Setmelanotide (RM-493, BIM-22493, IRC-022493) is a peptide, non-selective melanocortin receptor agonist with binding Ki of 3.9/10/2.1 for hMC1R/hMC3R/hMC4R, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $248 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $588 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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Setmelanotide (RM-493, BIM-22493, IRC-022493) is a peptide, non-selective melanocortin receptor agonist with binding Ki of 3.9/10/2.1 for hMC1R/hMC3R/hMC4R, respectively.
Setmelanotide exhibits weak activity at MC5R (EC50>1 uM) and inactive at the mouse MC2R (EC50>10 uM).
Setmelanotide acutely improves glucose homeostasis, causes weight loss and improves hyperinsulinemia and fatty liver in diet induced obese mice.
| M.Wt | 1117.309 | |
| Formula | C49H68N18O9S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO |
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| Chemical Name/SMILES |
L-Cysteinamide, N2-acetyl-L-arginyl-L-cysteinyl-D-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-, cyclic (2→8)-disulfide |
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1. Kumar KG, et al. Peptides. 2009 Oct;30(10):1892-900.
2. Chen KY, et al. J Clin Endocrinol Metab. 2015 Apr;100(4):1639-45.
3. Bischof JM, et al. Br J Pharmacol. 2016 Sep;173(17):2614-21.
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