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Chemical Structure : Sibiriline
Catalog No.: PC-70204Not For Human Use, Lab Use Only.
Sibiriline is a specific competitive RIPK1 inhibitor with IC50 of 1.03 uM, 100-fold less potent for RIPK3.
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Sibiriline is a specific competitive RIPK1 inhibitor with IC50 of 1.03 uM, 100-fold less potent for RIPK3.
Sibiriline inhibits both TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis in FADD-deficient Jurkat cells (EC50=1.2 uM).
Sibiriline selectively inhibits necroptotic cell death induced by various death ligands in human or mouse cells while not protecting from caspase-dependent apoptosis.
Sibiriline protects mice from concanavalin A-induced hepatitis.
| M.Wt | 210.236 | |
| Formula | C13H10N2O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Le Cann F, et al. FEBS J. 2017 Jul 17. doi: 10.1111/febs.14176.
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