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Chemical Structure : Simtuzumab
CAS No.:
Catalog No.: PC-Ab1092Not For Human Use, Lab Use Only.
Simtuzumab (SIM, GS-6624) is a humanized IgG1 antibody against lysyl oxidase like-2 (LOXL2). Simtuzumab binds to LOXL2, was shown to have a role in suppressing bleomycin-induced pulmonary fibrosis in a murine model. pecifically target and block the LOXL2 which has been assigned to an important role in fibrosis. Besidesm, LOXL2 is one of several secreted copper-binding amine oxidases that oxidize primary amine substrates to aldehydes. It is widely expressed, particularly in placenta, uterus, and
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $358 | In stock | |
| 5 mg | $758 | In stock | |
| 10 mg | $1280 | In stock | |
| 100 mg | Get quote |
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Simtuzumab (SIM, GS-6624) is a humanized IgG1 antibody against lysyl oxidase like-2 (LOXL2). Simtuzumab binds to LOXL2, was shown to have a role in suppressing bleomycin-induced pulmonary fibrosis in a murine model. pecifically target and block the LOXL2 which has been assigned to an important role in fibrosis. Besidesm, LOXL2 is one of several secreted copper-binding amine oxidases that oxidize primary amine substrates to aldehydes. It is widely expressed, particularly in placenta, uterus, and prostate. LOXL2 is upregulated during cancer progression and promotes cell migration and tumor cell invasiveness.
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| Formula | Human IgG4-Kappa | |
| Appearance | Solid | |
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| Solubility |
PBS, pH 7.0 Contains no stabilizers or preservatives |
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