Chemical Structure : Simvastatin
CAS No.: 79902-63-9
Catalog No.: PC-45300Not For Human Use, Lab Use Only.
A potent, competitive inhibitor of HMG-CoA reductase (HMGCR) with Kd of 0.1-0.2 nM.
Packing | Price | Stock | Quantity |
---|---|---|---|
100 mg | $80 | In stock | |
200 mg | $104 | In stock | |
500 mg | $208 | In stock |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
A potent, competitive inhibitor of HMG-CoA reductase (HMGCR) with Kd of 0.1-0.2 nM; inhibits cholesterol synthesis in mouse L-M cell (fibroblast), rat H4II E cell (liver), and human Hep G2 cell (liver) with IC50 of 19.3 nM, 13.3 nM and 15.6 nM, respectively; also shows anti-inflammatory activity in inflammatory arthritis.
Dyslipidemia
Approved
M.Wt | 418.5662 | |
Formula | C25H38O5 | |
Appearance | Solid | |
Storage |
|
|
Solubility |
10 mM in DMSO |
|
Chemical Name/SMILES |
Butanoic acid, 2,2-dimethyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester |
1. Kureishi Y, et al. Nat Med. 2000 Sep;6(9):1004-10.
2. Slater EE, et al. Drugs. 1988;36 Suppl 3:72-82.
3. Leung BP, et al. J Immunol. 2003 Feb 1;170(3):1524-30.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright