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Chemical Structure : Sivelestat
CAS No.: 127373-66-4
Catalog No.: PC-45264Not For Human Use, Lab Use Only.
Sivelestat (EI-546;LY-544349;ONO-5046) is a potent, specific and competitive inhibitor of human neutrophil elastase with IC50 of 44 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg (Free Sample) | $18 | In stock | |
| 10 mg | $78 | In stock | |
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | Get quote |
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Sivelestat (EI-546;LY-544349;ONO-5046) is a potent, specific and competitive inhibitor of human neutrophil elastase with IC50 of 44 nM.
Sivelestat (EI-546;LY-544349;ONO-5046) also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse, does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G (>10 uM).
Sivelestat (EI-546;LY-544349;ONO-5046) attenuates LPS-induced acute lung inflammation in the hamster.
| M.Wt | 434.4629 | |
| Formula | C20H22N2O7S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Propanoic acid, 2,2-dimethyl-, 4-[[[2-[[(carboxymethyl)amino]carbonyl]phenyl]amino]sulfonyl]phenyl ester |
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1. Kawabata K, et al. Biochem Biophys Res Commun. 1991 Jun 14;177(2):814-20.
2. Yasui S, et al. Eur Respir J. 1995 Aug;8(8):1293-9.
3. Sakamaki F, et al. Am J Respir Crit Care Med. 1996 Jan;153(1):391-7.
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