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Chemical Structure : Smurf1 inhibitor 1
Catalog No.: PC-21307Not For Human Use, Lab Use Only.
Smurf1 inhibitor 1 is a potent, selective Smurf1 E3 ligase inhibitor with IC50 of 230 nM in in UbFluor assays, inhibits the catalytic HECT domain of Smurf1.
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Smurf1 inhibitor 1 is a potent, selective Smurf1 E3 ligase inhibitor with IC50 of 230 nM in in UbFluor assays, inhibits the catalytic HECT domain of Smurf1.
Smurf1 inhibitor 1 inhibit E2-Ub/Smurf1 transthiolation and Ub propargyl labeling of Smurf1.
Smurf1 inhibitor 1 also blocks the covalent labeling of Smurf1 with the UbPA suggesting that it inhibits the function of the Cterminal FAVE peptide and may destabilize the L-conformation of Smurf1 HECT domain, or block the catalytic cysteine.
Smurf1 inhibitor 1 does not inhibits closely related Smurf2 ligase and other E3 ligases WWP1, Nedd4-1, and NleL.
| M.Wt | 522.54 | |
| Formula | C24H25F3N4O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Patrick Chuong, et al. bioRxiv. 2023 Oct 14:2023.10.14.562361.
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