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Chemical Structure : Sotrastaurin
CAS No.: 425637-18-9
Catalog No.: PC-42543Not For Human Use, Lab Use Only.
Sotrastaurin (AEB071) is a potent, selective, orally available pan-PKC inhibitor with Ki of 0.22-3.2 nM for PKC isotypes.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $128 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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Sotrastaurin (AEB071) is a potent, selective, orally available pan-PKC inhibitor with Ki of 0.22-3.2 nM for PKC isotypes.
Sotrastaurin (AEB071) displays excellent selectivity against a broad panel of kinases (only GSK-3β IC50<1 uM).
Sotrastaurin (AEB071) inhibits early T-cell activation with no general antiproliferative activity, also inhibits β2-integrin-mediated T-cell adhesiveness.
Sotrastaurin (AEB071) prolongs rat heterotopic heart transplant survival in combination with adjunct immunosuppression agents.
| M.Wt | 438.4812 | |
| Formula | C25H22N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1H-Pyrrole-2,5-dione, 3-(1H-indol-3-yl)-4-[2-(4-methyl-1-piperazinyl)-4-quinazolinyl]- |
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1. Evenou JP, et al. J Pharmacol Exp Ther. 2009 Sep;330(3):792-801.
2. Wagner J, et al. J Med Chem. 2009 Oct 22;52(20):6193-6.
3. Budde K, et al. Am J Transplant. 2010 Mar;10(3):571-81.
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