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Chemical Structure : Splitomicin
CAS No.: 5690-03-9
Catalog No.: PC-70234Not For Human Use, Lab Use Only.
Splitomicin (1-Naphthalenepropanoic Acid) is a selecitve small molecule inhibitor of Sir2p histone deacetylase, displaying higher activity in vivo (minimal inhibitory concentration= 0.49 uM) than in vitro (IC50=60 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $128 | In stock | |
| 50 mg | $198 | In stock | |
| 100 mg | $328 | In stock | |
| 250 mg | Get quote |
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Splitomicin (1-Naphthalenepropanoic Acid) is a selecitve small molecule inhibitor of Sir2p histone deacetylase, displaying higher activity in vivo (minimal inhibitory concentration= 0.49 uM) than in vitro (IC50=60 uM).
Splitomicin less effectively inhibits yeast Hst1.
| M.Wt | 198.2 | |
| Formula | C13H10O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
1,2-dihydro-3H-naphtho[2,1-b]pyran-3-one |
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1. Bedalov A, et al. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):15113-8.
2. Hirao M, et al. J Biol Chem. 2003 Dec 26;278(52):52773-82.
3. Liu FC, et al. Eur J Pharmacol. 2012 Aug 5;688(1-3):68-75.
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