Stafib-2-CR

Chemical Structure : Stafib-2-CR

Catalog No.: PC-26211Not For Human Use, Lab Use Only.

Stafib-2-CR is highly potent, selective inhibitor of transcription factor STAT5b with IC50 of 26 nM, shows 69-fold selectivity over STAT5a.

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Biological Activity

Stafib-2-CR is highly potent, selective inhibitor of transcription factor STAT5b with IC50 of 26 nM, shows 69-fold selectivity over STAT5a.
Stafib-2-CR displays 400-2700 fold selectivity against the other STAT proteins.
Stafib-2-CR binds to STAT5b with ITC Kd of 94 nM, fourfold higher affinity than Stafib-2 (Cat# PC-61167).

Physicochemical Properties

M.Wt	670.50
Formula	C30H28N2O12P2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-(4-((4-phenoxyphenyl)carbamoyl)phenoxy)acetyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diyl bis(dihydrogen phosphate)

References

1. Münzel T, et al. Chemistry. 2025 Nov 30:e02809.

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Stafib-2-CR

Biological Activity

Physicochemical Properties

References

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