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Chemical Structure : Sudemycin E
Catalog No.: PC-62421Not For Human Use, Lab Use Only.
Sudemycin E is an alternative splicing inhibitor that binds to the U2 small nuclear ribonucleoprotein (snRNP) component SF3B1, causes a rapid change in alternative pre-messenger RNA splicing.
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Sudemycin E is an alternative splicing inhibitor that binds to the U2 small nuclear ribonucleoprotein (snRNP) component SF3B1, causes a rapid change in alternative pre-messenger RNA splicing; changes overall gene expression and arrest in the G2 phase of the cell cycle, and causes a loss of the H3K36me3 modification in chromatin encoding these exons; induces changes in chromatin modifications that result in chromatin condensation.
| M.Wt | 491.625 | |
| Formula | C27H41NO7 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Convertini P, et al. Nucleic Acids Res. 2014 Apr;42(8):4947-61.
2. Thénoz M, et al. Retrovirology. 2014 Dec 18;11:119.
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