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Sudemycin K

Chemical Structure : Sudemycin K

CAS No.: 2071636-70-7

Sudemycin K

Catalog No.: PC-62422Not For Human Use, Lab Use Only.

Sudemycin K is a synthetic antitumor splicing inhibitor with IC50 of 15 nM (MCL1 alternative splicing regulation), shows cytotoxicity in HeLa cells with IC50 of 2.3 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Sudemycin K is a synthetic antitumor splicing inhibitor with IC50 of 15 nM (MCL1 alternative splicing regulation), shows cytotoxicity in HeLa cells with IC50 of 2.3 nM; has an IC50 of 250 nM in vitro spliceosome (A3’ complex) formation assays.

Physicochemical Properties

M.Wt 486.697
Formula C29H46N2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(S,Z)-N-((1R,4R)-4-((2E,4E)-5-((3R,5S)-7,7-dimethyl-1,6-dioxaspiro[2.5]octan-5-yl)-3-methylpenta-2,4-dien-1-yl)cyclohexyl)-4-isobutyramidopent-2-enamide

References

1. Makowski K, et al. ACS Chem Biol. 2017 Jan 20;12(1):163-173.

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