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Chemical Structure : Sunitinib
CAS No.: 557795-19-4
Catalog No.: PC-42490Not For Human Use, Lab Use Only.
A multi-targeted RTK inhibitor that targets VEGFR2 (Flk-1) and PDGFRβ with Ki of 8 nM and 9 nM respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 200 mg | $64 | In stock | |
| 500 mg | $80 | In stock |
Bulk size, bulk discount!
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A multi-targeted RTK inhibitor that targets VEGFR2 (Flk-1) and PDGFRβ with Ki of 8 nM and 9 nM respectively; displays >10-fold higher selectivity over FGFR-1, EGFR, Cdk2, Met, IGFR-1, Abl, and Src; also inhibits phosphorylation of wild-type FLT3, FLT3-ITD, and FLT3-Asp835 with IC50 of 250 nM, 50 nM, and 30 nM; regresses FLT3-ITD tumors in the subcutaneous tumor xenograft model.
Gastric Cancer
Approved
| M.Wt | 398.4738 | |
| Formula | C22H27FN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 25 mg/mL |
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| Chemical Name/SMILES |
1H-Pyrrole-3-carboxamide, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl- |
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1. Sun L, et al. J Med Chem. 2003 Mar 27;46(7):1116-9.
2. O'Farrell AM, et al. Blood. 2003 May 1;101(9):3597-605.
3. Mendel DB, et al. Clin Cancer Res. 2003 Jan;9(1):327-37.
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