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Suramin

Chemical Structure : Suramin

CAS No.: 145-63-1

Suramin

Catalog No.: PC-46930Not For Human Use, Lab Use Only.

An antitrypansomal drug that also possesses antitumor activity.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

An antitrypansomal drug that also possesses antitumor activity; inhibits CRL (Cullin-RING E3 ubiquitin ligases) activity by disrupting its ability to recruit Cdc34; induces accumulation of CRL substrates; also inhibits multiple viruses (ZIKVs, EV71).

Parasite Infection

Approved

Physicochemical Properties

M.Wt 1297.28
Formula C51H40N6O23S6
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1,3,5-Naphthalenetrisulfonic acid, 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-

References

1. Wu K, et al. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2011-8.

2. Ren P, et al. Sci Rep. 2017 Feb 20;7:42902.

3. Albulescu IC, et al. Antiviral Res. 2017 Jul;143:230-236.

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