Suramin sodium salt
(Suramin hexasodium salt, BAY-205, NF-060)
Catalog No.: PC-46931Not For Human Use, Lab Use Only.
Suramin sodium salt (BAY-205, NF-060) is an antitrypansomal drug that also possesses antitumor activity, inhibits CRL (Cullin-RING E3 ubiquitin ligases) activity by disrupting its ability to recruit Cdc34.
Suramin sodium salt (BAY-205, NF-060) is an antitrypansomal drug that also possesses antitumor activity, inhibits CRL (Cullin-RING E3 ubiquitin ligases) activity by disrupting its ability to recruit Cdc34.
Suramin also potently inhibits sirtuins: SirT1 (IC50=297 nM), SirT2 (IC50=1.15 μM), and SirT5 (IC50=22 μM).
Suramin induces accumulation of CRL substrates.
Suramin also inhibits multiple viruses (ZIKVs, EV71).
Physicochemical Properties
M.Wt
1429.171
Formula
C51H34N6Na6O23S6
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
H2O: ≥ 200 mg/mL; DMSO: 5.6 mg/mL (Need warming)
Chemical Name/SMILES
1,3,5-Naphthalenetrisulfonic acid, 8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bis-, sodium salt (1:6)
References
1. Wu K, et al. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2011-8.
2. Ren P, et al. Sci Rep. 2017 Feb 20;7:42902.
3. Albulescu IC, et al. Antiviral Res. 2017 Jul;143:230-236.
