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Syk-IN-23

Chemical Structure : Syk-IN-23

CAS No.: 2040321-29-5

Syk-IN-23

Catalog No.: PC-62789Not For Human Use, Lab Use Only.

Syk-IN-23 is a potent, selective Syk kinase inhibitor with IC50 of 20 nM, possesses good PK in both rat and dog and demonstrated efficacy in rat CIA model.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    Syk-IN-23 is a potent, selective Syk kinase inhibitor with IC50 of 20 nM, possesses good PK in both rat and dog and demonstrated efficacy in rat CIA model.

    Physicochemical Properties

    M.Wt 474.469
    Formula C22H24F2N6O4
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    methyl (R)-(8-((4-((2,2-difluoroethyl)amino)furo[3,2-d]pyrimidin-2-yl)amino)-5,5-dimethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)carbamate

    References

    1. Hoemann M, et al. Bioorg Med Chem Lett. 2016 Nov 15;26(22):5562-5567.

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