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Chemical Structure : SynuClean-D
CAS No.: 685121-45-3
Catalog No.: PC-35683Not For Human Use, Lab Use Only.
SynuClean-D (SC-D) is a novel, small molecule inhibitor of α-synuclein (α-Syn) aggregation, incubation of 70 uM α-Syn with 100 uM SC-D impacted α-Syn aggregation in vitro, as monitored by Th-T fluorescence.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $358 | In stock | |
| 10 mg | $558 | In stock | |
| 25 mg | $898 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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SynuClean-D (SC-D) is a novel, small molecule inhibitor of α-synuclein (α-Syn) aggregation, incubation of 70 uM α-Syn with 100 uM SC-D impacted α-Syn aggregation in vitro, as monitored by Th-T fluorescence。
SynuClean-D significantly reduces the in vitro aggregation of wild-type α-synuclein and the familiar A30P and H50Q variants in a substoichiometric molar ratio, prevents fibril propagation in protein-misfolding cyclic amplification assays and decreases the number of α-synuclein inclusions in human neuroglioma cells。
SynuClean-D binds to cavities in mature α-synuclein fibrils and displays a strong fibril disaggregation activity。
SynuClean-D significantly reduces the toxicity exerted by α-synuclein, also rescues dopaminergic neurons from α-synuclein-induced degeneration in Parkinson's disease models.
| M.Wt | 354.201 | |
| Formula | C13H5F3N4O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-hydroxy-5-nitro-6-(3-nitrophenyl)-4-(trifluoromethyl)nicotinonitrile |
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1. Pujols J, et al. Proc Natl Acad Sci U S A. 2018 Sep 24. pii: 201804198.
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