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Chemical Structure : Synucleozid hydrochloride
CAS No.: 2741856-68-6
Catalog No.: PC-38593Not For Human Use, Lab Use Only.
Synucleozid hydrochloride (NSC 377363) is a small molecule that targets the IRE structure and inhibits SNCA gene translation in cells, directly targets the α-synuclein mRNA 5'UTR at the designed site.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $228 | In stock | |
| 10 mg | $378 | In stock | |
| 50 mg | $858 | In stock | |
| 100 mg | $1480 | In stock | |
| 1 g | Get quote |
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Synucleozid hydrochloride (NSC 377363) is a small molecule that targets the IRE structure and inhibits SNCA gene translation in cells, directly targets the α-synuclein mRNA 5'UTR at the designed site.
Synucleozid decreases 2-AP emission with an EC50 of 2.7 uM.
Synucleozid binds and stabilizes the SNCA IRE in cells at a specific structural element.
Synucleozid selectively reduces α-synuclein protein levels by decreasing the amount of SNCA mRNA loaded into polysomes, mechanistically providing a cytoprotective effect in cells.
| M.Wt | 404.902 | |
| Formula | C22H21ClN6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1H-Indole-6-carboximidamide, 2-[4-[[4-(aminoiminomethyl)phenyl]amino]phenyl]-, hydrochloride (1:1) |
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1. Zhang P, et al. Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1457-1467.
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