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Chemical Structure : T-521
CAS No.: 891020-54-5
Catalog No.: PC-63063Not For Human Use, Lab Use Only.
T-521 is a novel PLK1 PBD (Polo-box domain) inhibitor that specifically inhibits the PBD of PLK1 (IC50=1.22 uM), but not those of Plk2-3.
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|---|---|---|---|
| 5 mg | $498 | In stock | |
| 10 mg | $798 | In stock | |
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| 100 mg | Get quote |
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T-521 is a novel PLK1 PBD (Polo-box domain) inhibitor that specifically inhibits the PBD of PLK1 (IC50=1.22 uM), but not those of Plk2-3.
T-521 impedes the interaction between Plk1 and Bub1, exhibits dramatic mitotic defects in HeLa cells.
T-521 suppresses the growth of A549 cells in xenograft nude mice.
| M.Wt | 512.43 | |
| Formula | C26H27Cl2N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
5-(ethylsulfonyl)-2-(4-fluorophenyl)-4-(phenylsulfonyl)oxazole |
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1. Chen Y, et al. Oncotarget. 2017 Jan 3;8(1):1234-1246.
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