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Chemical Structure : T2AA
Catalog No.: PC-72920Not For Human Use, Lab Use Only.
T2AA (T2 amino alcohol) is a small molecule proliferating cell nuclear antigen (PCNA) inhibitor, inhibits interaction of PCNA/PIP-box peptide with IC50 of 1 uM.
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T2AA (T2 amino alcohol) is a small molecule proliferating cell nuclear antigen (PCNA) inhibitor, inhibits interaction of PCNA/PIP-box peptide with IC50 of 1 uM.
T2AA also inhibits interaction of PCNA and full-length p21 protein.
T2AA abolished interaction of PCNA and DNA polymerase δ in cellular chromatin, arrested cancer cells in S-phase, inhibited growth of cancer cells with induction of early apoptosis.
T2AA significantly inhibited translesion DNA synthesis on a cisplatin-cross-linked template in cells, induced significant increase in phospho(Ser139) histone H2AX induction and cell growth inhibition combined with cisplatin.;
| M.Wt | 511.09 | |
| Formula | C15H15I2NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Actis M, et al. Bioorg Med Chem. 2013 Apr 1;21(7):1972-7.
2. Inoue A, et al. J Biol Chem. 2014 Mar 7;289(10):7109-7120.
3. Wilson RH, et al. DNA Repair (Amst). 2017 Feb;50:22-35.
4. Ohayon D, et al. J Exp Med. 2019 Nov 4;216(11):2669-2687.
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