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T7117

Chemical Structure : T7117

CAS No.: 69056-38-8

T7117 (6R-BH4 dihydrochloride, Sapropterin dihydrochloride)

Catalog No.: PC-26612Not For Human Use, Lab Use Only.

T7117 (6R-BH4 dihydrochloride) is a specific small molecule inhibitor that disrupts the TRIM25-HIF-1α interaction, exerts potent anti‑tumor effects in GBM, also is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

T7117 (6R-BH4 dihydrochloride) is a specific small molecule inhibitor that disrupts the TRIM25-HIF-1α interaction, exerts potent anti‑tumor effects in GBM, also is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations.

Physicochemical Properties

M.Wt 314.17
Formula C9H17Cl2N5O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(R)-2-Amino-6-((1R,2S)-1,2-dihydroxypropyl)-5,6,7,8-tetrahydropteridin-4(1H)-one dihydrochloride

References

1. Hui Huang, et al. Cell Death Dis. 2026 Apr 22. doi: 10.1038/s41419-026-08757-3.

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