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Chemical Structure : TACK molecule Pyr01
CAS No.: 2560576-15-8
Catalog No.: PC-20150Not For Human Use, Lab Use Only.
TACK molecule Pyr01 is a potent targeted activator of cell kill (TACK) small molecule, binds to HIV-1 reverse transcriptase-p66 domain of monomeric Gag-Pol.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $328 | In stock | |
| 10 mg | $528 | In stock | |
| 25 mg | $898 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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TACK molecule Pyr01 is a potent targeted activator of cell kill (TACK) small molecule, binds to HIV-1 reverse transcriptase-p66 domain of monomeric Gag-Pol.
Pyr01 exhibits potent antiviral activity and selectively eliminate infected CD4+ T cells isolated from people living with HIV-1.
Pyr01 act as allosteric modulator to accelerate dimerization, resulting in HIV-1+ cell death through premature intracellular viral protease activation.
| M.Wt | 502.35 | |
| Formula | C21H13F7N4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-(difluoromethyl)-3-((1-((5-fluoro-2-oxo-1,2-dihydropyridin-3-yl)methyl)-6-oxo-4-(1,1,2,2-tetrafluoroethyl)-1,6-dihydropyrimidin-5-yl)oxy)-2-methylbenzonitrile |
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1. Carl J Balibar, et al. Sci Transl Med. 2023 Feb 22;15(684):eabn2038.
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