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Chemical Structure : TAK-063
CAS No.: 1238697-26-1
Catalog No.: PC-43051Not For Human Use, Lab Use Only.
TAK-063 (Balipodect) is a highly potent, selective, orally active PDE10A inhibitor with IC50 of 0.3 nM, displays >15,000-fold selectivity over other PDE subtypes.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 25 mg | $158 | In stock | |
| 50 mg | $248 | In stock | |
| 100 mg | Get quote |
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TAK-063 (Balipodect) is a highly potent, selective, orally active PDE10A inhibitor with IC50 of 0.3 nM, displays >15,000-fold selectivity over other PDE subtypes.
TAK-063 increases cAMP and cGMP levels in the rodent striatum and upregulates phosphorylation levels of key substrates of cAMP- and cGMP-dependent protein kinases.
TAK-063 strongly suppresses MK-801-induced hyperlocomotion in rodents (0.3 and 1 mg/kg p.o), improves cognitive functions associated with schizophrenia in rodent models,
| M.Wt | 428.4185 | |
| Formula | C23H17FN6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4(1H)-Pyridazinone, 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)- |
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1. Kunitomo J, et al. J Med Chem. 2014 Nov 26;57(22):9627-43.
2. Suzuki K, et al. J Pharmacol Exp Ther. 2015 Mar;352(3):471-9.
3. Shiraishi E, et al. J Pharmacol Exp Ther. 2016 Mar;356(3):587-95.
4. Suzuki K, et al. Neuropsychopharmacology. 2016 Aug;41(9):2252-62.
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