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Chemical Structure : TAK-220
CAS No.: 333994-00-6
Catalog No.: PC-45771Not For Human Use, Lab Use Only.
TAK-220 (TAK220) is a potent, specific, orally bioavailable CCR5 antagonist that blocks the binding of MIP-1α to CCR5 with IC50 of 1.4 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $288 | In stock | |
| 10 mg | $458 | In stock | |
| 25 mg | Get quote | ||
| 100 mg | Get quote |
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TAK-220 (TAK220) is a potent, specific, orally bioavailable CCR5 antagonist that blocks the binding of MIP-1α to CCR5 with IC50 of 1.4 nM.
TAK-220 shows no affinity for CCR1, CCR2b, CCR3, CCR4, or CCR7.
TAK-220 inhibits the replication of 6 CCR5-using (R5) HIV-1 clinical isolates in peripheral blood mononuclear cells (PBMCs) with mean EC90 of 13 nM.
TAK-220 selectively inhibits R5 HIV-1 replication by interfering with coreceptor-mediated entry of the virus into host cells; exhibits a good pharmacokinetic profile in monkeys.
| M.Wt | 553.1353 | |
| Formula | C31H41ClN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-Piperidinecarboxamide, 1-acetyl-N-[3-[4-[[4-(aminocarbonyl)phenyl]methyl]-1-piperidinyl]propyl]-N-(3-chloro-4-methylphenyl)- |
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1. Tremblay CL, et al. Antimicrob Agents Chemother. 2005 Aug;49(8):3483-5.
2. Takashima K, et al. Antimicrob Agents Chemother. 2005 Aug;49(8):3474-82.
3. Imamura S, et al. J Med Chem. 2006 May 4;49(9):2784-93.
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