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Chemical Structure : TAK-715
CAS No.: 303162-79-0
Catalog No.: PC-42599Not For Human Use, Lab Use Only.
A potent, selective, orally active p38α MAPK inhibitor with IC50 of 7.1 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 50 mg | $264 | In stock | |
| 250 mg | Get quote |
Bulk size, bulk discount!
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A potent, selective, orally active p38α MAPK inhibitor with IC50 of 7.1 nM; displays >20-fold selectvity over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1; inhibits LPS-stimulated release of TNF-alpha from THP-1 with IC50 of 48 nM; exerts significant efficacy in rat adjuvant-induced arthritis model.
Rheumatoid Arthritis
Phase 2 Discontinued
| M.Wt | 399.508 | |
| Formula | C24H21N3OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Benzamide, N-[4-[2-ethyl-4-(3-methylphenyl)-5-thiazolyl]-2-pyridinyl]- |
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1. Miwatashi S, et al. J Med Chem. 2005 Sep 22;48(19):5966-79.
2. Verkaar F, et al. Chem Biol. 2011 Apr 22;18(4):485-94.
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