TAM-16 is a benzofuran class inhibitor of M. tuberculosis Pks13 (Polyketide Synthase 13 with IC50 of 0.32 uM.
TAM-16 show highly potent in vitro bactericidal activity against drug-susceptible and drug-resistant clinical isolates of M. tuberculosis (MICs: 0.06-0.25 uM).
TAM-16 exhibits in vivo efficacy in multiple mouse models of TB infection, has excellent pharmacological and safety profiles.
