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Chemical Structure : TAS-204
Catalog No.: PC-49642Not For Human Use, Lab Use Only.
TAS-204 (TAS204) is a potent, specific hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, inhibits recombinant human H-PGDS with IC50 of 24.0 nM.
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TAS-204 (TAS204) is a potent, specific hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, inhibits recombinant human H-PGDS with IC50 of 24.0 nM.
TAS-204 showed no inhibitory activities against COX-1, COX-2, microsomal PGE synthase or L-PGDS up to 10 uM.
TAS204 at 3.75, 7.5, 15 and 30 mg/kg dose-dependently inhibited the PGD2 production in in vivo.
TAS-204 reduced osinophil infiltration in nasal lavage fluid and nasal hyperresponsiveness to histamine in guinea pig model of experimental allergic rhinitis.
| M.Wt | 438.91 | |
| Formula | C23H23ClN4O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Daisuke Kajiwara, et al. Eur J Pharmacol. 2011 Sep 30;667(1-3):389-95.
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