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Chemical Structure : TASP0376377
Catalog No.: PC-61564Not For Human Use, Lab Use Only.
TASP0376377 is a potent, selective prostaglandin D2 receptor (CRTH2) antagonist with binding IC50 of 19 nM.
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TASP0376377 is a potent, selective prostaglandin D2 receptor (CRTH2) antagonist with binding IC50 of 19 nM; shows excellent functional antagonist activity in chemotaxis assay with IC50 of 23 nM, displays sufficient selectivity for binding to CRTH2 over the DP1 prostanoid receptor (IC50>1 yM), COX-1 and COX-2 enzymes (IC50>10 uM).
| M.Wt | 479.313 | |
| Formula | C25H16Cl2N2O4 | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Nishikawa-Shimono R, et al. Bioorg Med Chem Lett. 2012 May 1;22(9):3305-10.
2. Nishikawa-Shimono R, et al. Bioorg Med Chem. 2013 Dec 15;21(24):7674-85.
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