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TBAJ-5307

Chemical Structure : TBAJ-5307

CAS No.: 2583850-72-8

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TBAJ-5307 ((-)-TBAJ5307)

Catalog No.: PC-21661Not For Human Use, Lab Use Only.

TBAJ-5307 is a broad spectrum anti-non-tuberculous mycobacteria (NTM) inhibitor targeting FO-domain of F1FO-ATP synthase, shows MIC50 of 4.5 nM and 6 nM against the Mab subsp. abscessus smooth strain and rough strain respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TBAJ-5307 is a broad spectrum anti-non-tuberculous mycobacteria (NTM) inhibitor targeting FO-domain of F1FO-ATP synthase, shows MIC50 of 4.5 nM and 6 nM against the Mab subsp. abscessus smooth strain and rough strain respectively.

    Physicochemical Properties

    M.Wt 627.54
    Formula C30H35BrN4O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-1-(2,3-dimethoxypyridin-4-yl)-2-(2,6-dimethoxypyridin-4-yl)-4-(dimethylamino)butan-2-ol

    References

    1. Priya Ragunathan, et al. J Biol Chem. 2024 Jan 2:105618.

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