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Chemical Structure : TCMDC-135051
CAS No.: 2413716-15-9
Catalog No.: PC-73056Not For Human Use, Lab Use Only.
TCMDC-135051 is a potent PfCLK3 inhibitor with IC50 of 40 nM.
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| 5 mg | $298 | In stock | |
| 10 mg | $478 | In stock | |
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TCMDC-135051 is a potent PfCLK3 inhibitor with IC50 of 40 nM.
TCMDC-135051 rapidly killed P. falciparum at the trophozoite to schizont stages as well as preventing the development of stage V gametocytes and inhibiting the development of liver stage parasites.
TCMDC-135051 also showed equivalent in vitro kinase activity at CLK3 from P. falciparum, Plasmodium berghei (mouse malaria), Plasmodium vivax (human malaria), and Plasmodium knowlesi (monkey and human malaria).
TCMDC-135051 inhibits in live parasite viability (parasiticidal) assays using laboratory strain 3D7 (chloroquine-sensitive) P. falciparum with EC50 of 180 nM.
| M.Wt | 471.601 | |
| Formula | C29H33N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(2-(5-((diethylamino)methyl)-2-methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-2-isopropylbenzoic acid |
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1. Alam MM, et al. Science. 2019 Aug 30;365(6456). pii: eaau1682.
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