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TDI-2760

Chemical Structure : TDI-2760

CAS No.: 956128-08-8

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TDI-2760 (TDI2760)

Catalog No.: PC-63202Not For Human Use, Lab Use Only.

TDI-2760 is a small molecule Aβ-aggregation inhibitor that not only shows a strong inhibitory efficacy toward the Aβ-fibrinogen interaction (IC50=1.67 uM) but also retains potency toward the Aβ42 aggregation inhibition process.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    TDI-2760 is a small molecule Aβ-aggregation inhibitor that not only shows a strong inhibitory efficacy toward the Aβ-fibrinogen interaction (IC50=1.67 uM) but also retains potency toward the Aβ42 aggregation inhibition process.
    TDI-2760 restores the Aβ42-induced decrease in fibrin clot turbidity without affecting normal clotting in an in vitro clotting assay.
    TDI-2760 effectively inhibits Aβ42 fibrillization and modulates Aβ42-induced contact system activation.

    Physicochemical Properties

    M.Wt 306.369
    Formula C18H18N4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-(3-(dimethylamino)phenoxy)-N-phenylpyrimidin-2-amine

    References

    1. Singh PK, et al. Biochemistry. 2018 Feb 27;57(8):1399-1409.

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