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Chemical Structure : TDI-2760
Catalog No.: PC-63202Not For Human Use, Lab Use Only.
TDI-2760 is a small molecule Aβ-aggregation inhibitor that not only shows a strong inhibitory efficacy toward the Aβ-fibrinogen interaction (IC50=1.67 uM) but also retains potency toward the Aβ42 aggregation inhibition process.
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TDI-2760 is a small molecule Aβ-aggregation inhibitor that not only shows a strong inhibitory efficacy toward the Aβ-fibrinogen interaction (IC50=1.67 uM) but also retains potency toward the Aβ42 aggregation inhibition process.
TDI-2760 restores the Aβ42-induced decrease in fibrin clot turbidity without affecting normal clotting in an in vitro clotting assay.
TDI-2760 effectively inhibits Aβ42 fibrillization and modulates Aβ42-induced contact system activation.
| M.Wt | 306.369 | |
| Formula | C18H18N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Singh PK, et al. Biochemistry. 2018 Feb 27;57(8):1399-1409.
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