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Chemical Structure : TG-0205221
Catalog No.: PC-72196Not For Human Use, Lab Use Only.
TG-0205221 (MPI8) is a potent SARS-CoV 3CL protease (3CLpro) inhibitor with Ki of 53/68 nM against SARS-CoV 3CLpro/ HCoV 229E 3CLpro, respectively.
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TG-0205221 (MPI8) is a potent SARS-CoV 3CL protease (3CLpro) inhibitor with Ki of 53/68 nM against SARS-CoV 3CLpro/ HCoV 229E 3CLpro, respectively.
TG-0205221 showed remarkable activity against SARS CoV (IC50=0.16 uM) and HCoV 229E (IC50=0.6 uM) replications by reducing the viral titer by 4.7 log (at 5 µM) for SARS CoV and 5.2 log (at 1.25 µM) for HCoV 229E.
| M.Wt | 600.757 | |
| Formula | C32H48N4O7 | |
| Appearance | Solid | |
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1. Syaulan Yang, et al. J Med Chem. 2006 Aug 10;49(16):4971-80.
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