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Chemical Structure : TG100-115
CAS No.: 677297-51-7
Catalog No.: PC-42319Not For Human Use, Lab Use Only.
TG100-115 (TG100115) is a potent, selective PI3Kγ/δ with IC50 of 83/235 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $108 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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TG100-115 (TG100115) is a potent, selective PI3Kγ/δ with IC50 of 83/235 nM, respectively.
TG100-115 shows no significant inhibitory activity against pI3Kα and β, and a broad panel of kinases (IC50>1 uM).
TG100-115 potently inhibits edema and inflammation in response to multiple mediators known to participate in myocardial infarction, such as VEGF and platelet-activating factor, without effect on endothelial cell mitogenesis。
TG100-115 provides potent cardioprotection, reduces infarct development and preserves myocardial function in animal MI models.
| M.Wt | 346.3428 | |
| Formula | C18H14N6O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Phenol, 3,3'-(2,4-diamino-6,7-pteridinediyl)bis- |
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1. Doukas J, et al. Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19866-71.
2. Doukas J, et al. J Pharmacol Exp Ther. 2009 Mar;328(3):758-65.
3. Kaneda MM, et al. Cancer Discov. 2016 Aug;6(8):870-85.
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