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Chemical Structure : TG4-155
Catalog No.: PC-62029Not For Human Use, Lab Use Only.
TG4-155 is a potent and selective prostaglandin EP2 receptor antagonist with Kb of 2.4 nM.
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TG4-155 is a potent and selective prostaglandin EP2 receptor antagonist with Kb of 2.4 nM; displays 4,730-fold selectivity over EP4, >500-fold selectivity over human BLT1, EP1, EP3, and FP receptors, and 7-fold selectivity against human DP1 receptor; displays robust inhibition of PGE2-induced cAMP accumulation in C6G cells stably expressing mouse EP2 receptor; significantly reduces SE-induced neurodegeneration in mice.
| M.Wt | 394.5 | |
| Formula | C23H26N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Jiang J, et al. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3149-54.
2. Jiang J, et al. J Pharmacol Exp Ther. 2013 Feb;344(2):360-7.
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