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Chemical Structure : TG8-260
Catalog No.: PC-72851Not For Human Use, Lab Use Only.
TG8-260 is a second-generation, potent, selective EP2 antagonist with Schild KB of 13.2 nM.
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TG8-260 is a second-generation, potent, selective EP2 antagonist with Schild KB of 13.2 nM.
TG8-260 displays 500-fold selectivity to EP2 against other prostanoid receptors.
TG8-260 has a plasma half-life of 2.14 h (PO) and excellent oral bioavailability (77.3%), TG8-260 is a potent inhibitor of CYP450 enzymes.
TG8-260 displays antagonistic activity on the induction of EP2 receptor-mediated inflammatory gene expression in microglia BV2-hEP2 cells.
TG8-260 reduces hippocampal neuroinflammation and gliosis after pilocarpine-induced status epilepticus in rats.
TG8-260 is a tool for investigating anti-inflammatory pathways in peripheral inflammatory disease animal models.
| M.Wt | 344.418 | |
| Formula | C21H20N4O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Radhika Amaradhi, et al. ACS Pharmacol Transl Sci. 2022 Jan 25;5(2):118-133.
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